靳雪娇，博士、副教授、硕士生导师、best365天目优秀青年学者，2018年于中国农业大学获得博士学位，同年入职该单位，期间在瑞典哥德堡大学从事博士后研究（2018年12月至2020年3月），入职以来主要从事蛋白质相变在胁迫响应和衰老中的作用机制研究以及林源化合物的抗衰老机理研究。

教学工作

承担本科生《蛋白质与酶工程》、《高级微生物研究法》、《探秘神奇的病毒世界》教学工作。

科研项目

1.国家自然科学基金面上项目, 32370036,酿酒酵母Sgt2相分离介导的氧化胁迫耐受机制, 2024.01-2027.12, 50万,主持

2.国家自然科学基金青年项目, 31800163, JB6细胞壁的三维结构、组成成分及其在JB6适应碳酸盐胁迫中的作用分析, 2019.01-2021.12, 27万,主持

3.浙江省自然科学基金, LY23C060001, Sgt2调控Sis1液-液相分离在维持蛋白质稳态中的作用机制研究, 2023.01-2025.12, 10万,主持

4.校科研发展基金, 2021LFR053, Sis1响应氧化胁迫发生相分离的调控机理研究, 2021.11-2024.11, 15万,主持

5.国家自然科学基金面上项目, 32371831,光强调控蜡质合成机制的研究--以小灌木蜡叶越橘为模型, 2024.01-2027.12, 50万,参与

6.国家自然科学基金青年项目, 32000387,酵母衰老过程中Yhb1生理性聚集对α-synuclein和synphilin-1细胞毒性的影响及其机制研究, 2021.01-2023.12, 24万,参与

7.浙江省自然科学基金青年项目, LQ19C070001, synphilin-1蛋白聚集体在酵母中与线粒体互作的原位结构及其对线粒体功能影响的分析, 2019.01-2021.12, 9万,参与

8.校科研发展基金, 2023LFR025,林源黄酮类化合物抗衰老活性筛选及机理研究, 2023.04-2026.05, 15万,参与

一作及通讯作者论文

1.Jin X^#, Zhou M^#, Chen S, Li D, Cao X^*, Liu B^*, Effects of pH alterations on stress- and aging-induced protein phase separation, Cellular and Molecular Life Sciences, 2022, 79(7):380

2.Jin X, Jiang Z, Zhang K, Wang P, Cao X, Yue N, Wang X, Zhang X, Li Y, Li D, Kang B, Zhang Y^*, Three-dimensional analysis of chloroplast structures associated with virus infection, Plant Physiology, 2018, 176(1): 282-294

3.Jin X^#, Zhang J^#, An T^#, Zhao H, Fu W, Li D, Liu S, Cao X^*, Liu B^*, A genome-wide screen in Saccharomyces cerevisiae reveals a critical role for oxidative phosphorylation in cellular tolerance to lithium hexafluorophosphate, Cells, 2021, 10(4): 888

4.Jin X^#, Cao X^#, Liu S^*, Liu B^*, Functional roles of poly(ADP-ribose) in stress granule formation and dynamics, Frontiers in Cell and Developmental Biology, 2021, 9: 671780

5.Jin X^#, Zhao H^#, Zhou M, Zhang J, An T, Fu W, Li D, Cao X^*, Liu B^*, Retromer complex and PI3K complex II-related genes mediate the yeast (Saccharomyces cerevisiae) sodium metabisulfite resistance response, Cells, 2021, 10(12):3512

6.Jin X, Cao X, Wang X, Jiang J, Wan J, Laliberte J^*, Zhang Y^*, Three-dimensional architecture and biogenesis of membrane structures associated with plant virus replication, Frontiers in Plant Science, 2018, 9:57

7.Jiang Z^#*,Jin X^#, Yang M^#, Pi Q, Cao Q, Li Z, Zhang Y, Wang X, Han C, Yu J, Li D^*, Barley stripe mosaic virus γb protein targets thioredoxin h-type 1 to dampen salicylic acid-mediated defenses, Plant Physiology, 2022, 189(3):1715-1727（共同一作）

8.Cao X^#,Jin X^#, Liu B^*, The involvement of stress granules in aging and aging-associated diseases, Aging Cell, 2020, 19(4): e13136（共同一作）

9.Wu Q^#, Cui Y^#,Jin X^#, Wang G^#, Yan L^#, Zhong C, Yu M, Li W, Wang Y, Wang L, et al., The CC-NB-LRR protein BSR1 from Brachypodium confers resistance to Barley stripe mosaic virus in gramineous plants by recognizing TGB1 movement protein, New Phytologist, 2022, 236(6):2233-2248（共同一作）

10.Qiu J, Zhang J, Zhao H, Wu C, Jin C, Hu X, Li J, Cao X, Liu S^*andJin X^*, Cellulose and JbKOBITO 1 mediate the resistance of NaHCO₃-tolerant chlorella to saline-alkali stress, Frontiers in Microbiology, 2023, 14:1285796

11.Xiang L^#，Wang Y^#, Liu S, Liu B,Jin X^*, Cao X^*, Targeting Protein Aggregates with natural products: an optional strategy for neurodegenerative diseases, International Journal of Molecular Sciences, 2023, 24(14):11275（共同通讯）

12.Guo L^#, Xu Z^#, Wang S^#, Nie Y, Ye X,Jin X^*, Zhu J^*, Wu W^*, Integrative multi-omics analysis of three early diverged rosid species reveals an ancient hierarchical cold-responsive regulatory network, Physiologia Plantarum, 2023, 175(2):e13892（共同通讯）

13.Cao X^#*, An T^#, Fu W, Zhang J, Zhao H, Li D,Jin X^*, Liu B^*, Genome-wide identification of cellular pathways and key genes that respond to sodium bicarbonate stress in Saccharomyces cerevisiae, Frontiers in Microbiology, 2022, 13:831973（共同通讯）

14.Fu W^#, Cao X^#*, An T, Zhao H, Zhang J, Li D,Jin X^*, Liu B^*, Genome-wide identification of resistance genes and transcriptome regulation in yeast to accommodate ammonium toxicity, BMC Genomics, 2022, 23(1):514（共同通讯）

专著章节

1.Jin X, Cao X, Liu B, Isolation of aged yeast cells using biotin-streptavidin affinity purification. In: Xiao W. (eds) Yeast Protocols, 2021, ISBN: 978-1-0716-0867-8

2.Cao X,Jin X, and Liu B, Genome-wide imaging-based phenomic screening using yeast (Saccharomyces cerevisiae) strain collections. In: Xiao W. (eds) Yeast Protocols, 2021, ISBN: 978-1-0716-0867-8

获奖荣誉

1.第七届全国大学生生命科学竞赛，国家三等奖，指导教师

2.2023年大学生创新创业训练项目，国家级，指导教师

3.浙江省第三届大学生环境生态科技创新大赛，省级一等奖，指导教师

4.浙江省第十四届大学生生命科学竞赛，省级二等奖，指导教师

5.教育部中国留学人员创新创业大赛，优胜奖

6.best365第三届大学生环境生态科技创新大赛，一等奖，指导教师

7.best365青年教师教学竞赛，特等奖

8.best365教师教学创新大赛，二等奖

联系方式

通讯地址:浙江省杭州市临安区武肃街666号国重楼503

邮 编: 311300

邮 箱: jinxuejiao1991@zafu.edu.cn