桂金山，教授，博士生导师，best365省部共建亚热带森林培育国家重点实验室-植物细胞壁功能基因组学研究团队负责人。主要围绕木竹材细胞壁形成过程中的重要科学问题和木材改良中亟待解决的关键技术，开展了较为系统的研究。已取得如下成果：1）鉴定到一系列与木材形成相关的类受体激酶，揭示了类受体激酶ASX调控木质部分化的分子机制；2）发现了木质素合成的“感应开关”LTF1，并利用该开关基因的原理，建立了木质素合成精准调控技术体系；3）揭示了Remorin蛋白在平衡植物生长与抗逆过程中的作用机制。研究结果已发表SCI论文19篇，其中以第一作者或共同通讯作者在Developmental Cell、Molecular Plant和New Phytologist等期刊上发表研究论文10篇，授权专利4项。2016年获得赛诺菲-中国科best365网页版登录上海生命科学研究院优秀青年人才奖；2017年入选中国科best365网页版登录青年创新促进会会员；2020年获得国家自然科学基金优秀青年科学基金资助。
研究方向
以杨树、竹子和水稻为材料，应用多种技术手段，探索细胞壁加厚过程中的关键信号及其传导途径。通过建立杨树类受体激酶的基因编辑突变体库，我们已成功鉴定多个影响次生木质部发育的关键类受体激酶。我们的研究重点包括：
1.类受体激酶介导木材细胞壁加厚的分子机制解析；
2. Remorin基因家族的演化与功能；
3.木材材性关键基因的定向演化。
研究团队致力于培育具有独立思考能力和探索精神的青年科学家。我们诚邀怀揣远大理想、聪明勤奋、品格坚韧、并具备自我管理能力的你加入我们，申请攻读博士或硕士学位（每年计划招收硕士研究生3-4名，博士研究生1-2名）。同时，我们计划招聘博士后2-3名，青年教师（事业编）1-2名，欢迎有志之士加盟！
学习与工作经历
1.学习经历
2002-2006：湖南农业大学，草业科学，农学学士
2006-2008：中国农业大学，草业科学，农学硕士
2008-2012：中国科best365网页版登录上海植物生理生态研究所，植物学，理学博士
2.工作经历
2012-2014：中国科best365网页版登录上海植物生理生态研究所，博士后
2014-2020：中国科best365网页版登录上海植物生理生态研究所，副研究员
2020-2021：中国科best365网页版登录上海植物生理生态研究所，研究员
2021-至今：best365，教授
教学工作
《生物技术新生研讨课》（本科生）
《农林生物技术前沿专题》（本科生）
《分子遗传学研究专题》（研究生）
科研项目
1.国家自然科学基金委员会，优青项目，2021-2023，在研，主持
2.国家自然科学基金委员会，面上项目，2020-2023，在研，主持
3.农业农村部，国家科技重大专项，2018-2020，已结题，主持
4.国家自然科学基金委员会，青年项目，2015-2017，已结题，主持
5.中国博士后科学基金会，特别资助，2014-2015，已结题，主持
6.中国科best365网页版登录上海生命科学研究院优秀青年人才领域前沿项目，2013-2015，已结题，主持
7.中国博士后科学基金会，面上资助2013-2015已结题，主持
论文与专著（#：第一作者，*：通讯作者）
(1) Zhi Xie#,Jinshan Gui#, Yu Zhong#, Bo Li, Jiayan Sun, Junhui Shen, Laigeng Li, Screening genome-editing knockouts reveals the receptor-like kinase ASX role in regulations of secondary xylem development inPopulus,New Phytologist, 2023, 238, 1972-1985.
(2) Siwei Lv#, Zengshun Lin#, Junhui Shen#, Laifu Luo, Qingguo Xu*, Laigeng Li*,Jinshan Gui*, OsTCP19 coordinates inhibition of lignin biosynthesis and promotion of cellulose biosynthesis to modify lodging resistance in rice.Journal of Experimental Botany,2023, 75(1): 123-136.
(3) Ping Zhu#, Yu Zhong#, Laifu Luo, Junhui Shen, Jiayan Sun, Laigeng Li*, Longjun Cheng*,Jinshan Gui*, The MPK6-LTF1L1 module regulates lignin biosynthesis in rice through a distinct mechanism fromPopulusLTF1,Plant Science,2023, 337: 111890.
(4)Shumin Cao#, Cheng Huang#, Laifu Luo, Zheng Shuai, Yu Zhong, Jiayan Sun,Jinshan Gui*, Laigeng Li*, Cell-specific suppression of 4-coumarate-CoA ligase gene reveals differential effect of lignin on cell physiological function inPopulus,Frontiers in Plant Science,2020, doi: 10.3389/fpls.2020.589729.
(5)Jinshan Gui*, Pui Ying Lam, Yuki Tobimatsu, Jiayan Sun, Cheng Huang, Shumin Cao, Yu Zhong, Toshiaki Umezawa*, Laigeng Li*,Fiber-specific regulation of lignin biosynthesis improves biomass quality inPopulus,New Phytologist,2020, 226(4): 1074-1087.
(6)Jinshan Gui*, Laifu Luo, Yu Zhong, Jiayan Sun, Toshiaki Umezawa, Laigeng Li*, Phosphorylation of LTF1, an MYB transcription factor inPopulus, acts as a sensory switch regulating lignin biosynthesis in wood cells,Molecular Plant,2019, 12(10): 1325-1337.
(7)Jinshan Gui, Shuai Zheng, Chang Liu, Junhui Shen, Jianming Li, Laigeng Li*,OsREM4.1 interacts with OsSERK1 to coordinate the interlinking between abscisic acid and brassinosteroid signaling in rice,Developmental Cell,2016, 38(2): 201-213.
(8)Jinshan Gui, Shuai Zheng, Junhui Shen and Laigeng Li*, Grain setting defect1 (GSD1) function in rice depends on S-acylation and interacts with actin 1 (OsACT1) at its C-terminal.Frontiers in Plant Science,2015, 6, 804.
(9)Jinshan Gui, Chang Liu, Junhui Shen, Laigeng Li*,Grain setting defect1, encoding a remorin protein, affects the grain setting in rice through regulating plasmodesmatal conductance,Plant Physiology,2014, 166(3): 1463-1478.
(10)Jinshan Gui, Junhui Shen, Laigeng Li*,Functional characterization of evolutionarily divergent 4-coumarate:coenzyme A ligases in rice,Plant Physiology,2011, 157(2): 574-586.
(11) Dongliang Song*,Jinshan Gui, Chenchen Liu, Jiayan Sun and Laigeng Li, Suppression of PtrDUF579-3 Expression Causes Structural Changes of the Glucuronoxylan inPopulus.Frontiers in Plant Science, 2016, 7, 493.
(12) Chang Liu, Shuai Zheng,Jinshan Gui, Chenjian Fu, Hasi Yu, Dongliang Song, Junhui Shen, Peng Qin, Xuanming Liu, Bin Han, Yuanzhu Yang*and Laigeng Li*, Shortened Basal Internodes encodes a gibberellin 2-oxidase and contributes to lodging resistance in rice.Molecular Plant, 2017, 11(2):288-299.
(13) Cheng Huang, Rui Zhang,Jinshan Gui, Yu Zhong and Laigeng Li*,The receptor-like kinase AtVRLK1 regulates secondary cell wall thickening,Plant Physiology, 2018, 177(2): 671-683.
(14) Yanbiao Zhou#, Cong Liu#, Dongying Tang#, Lu Yan#, Dan Wang, Yuanzhu Yang,Jinshan Gui, Xiaoying Zhao, Laigeng Li, Xiaodan Tang, Feng Yu, Jianglin Li, Lanlan Liu, Yonghua Zhu, Jianzhong Lin*and Xuanming Liu*, The Receptor-like Cytoplasmic Kinase STRK1 phosphorylates and activates CatC, thereby regulating H2O2 homeostasis and improving salt tolerance in rice.Plant Cell, 2018, 30, 1100-1118.
(15) Yingying Zhu#, Dongliang Song#, Rui Zhang, Laifu Luo, Shumin Cao, Cheng Huang, Jiayan Sun,Jinshan Guiand Laigeng Li*, A xylem-produced peptide PtrCLE20 inhibits vascular cambium activity inPopulus.Plant Biotechnology Journal, 2020, 18(1): 195-206.
(16)Jing-Shi Xue#, Baocai Zhang#, HuaDong Zhan#, Yong-Lin Lv, Xin-Lei Jia, TianHua Wang, Nai-Ying Yang, Yu-Xia Lou, Zai-Bao Zhang, Wen-Jing Hu,Jinshan Gui, Jianguo Cao, Ping Xu, Yihua Zhou, Jin-feng Hu, Laigeng Li*, Zhong-Nan Yang*, Phenylpropanoid derivatives are essential components of sporopollenin in vascular plants.Molecular Plant, 2020, doi: 10.1016/j.molp.2020.08.005.
(17) Laifu Luo, Yingying Zhu,Jinshan Gui, Tongmin Yin, Wenchun Luo, Jianquan Liu and Laigeng Li*, A Comparative Analysis of Transcription Networks Active in Juvenile and Mature Wood in Populus.Frontiers in plant science, 2021, doi: 10.3389/fpls.2021.675075.
(18) Hui Lin#, Muyang Wang#, Ying Chen, Kinya Nomura, Shugang Hui,Jinshan Gui, Xiawei Zhang, Yue Wu, Jiyun Liu, Qun Li, Yiwen Deng, Laigeng Li, Meng Yuan, Shiping Wang, Sheng Yang He, Zuhua He*, An MKP-MAPK protein phosphorylation cascade controls vascular immunity in plants.Science Advances,2022, 8. eabg8723.
(19) Sunil Kumar Sahu#, Min Liu#, Yewen Chen#,Jinshan Gui, Dongming Fang, Xiaoli Chen, Ting Yang, Chengzhong He, Le Cheng, JinlongYang, Durgesh Nandini Sahu, Linzhou Li, Hongli Wang, Weixue Mu, Jinpu Wei, Jie Liu, Yuxian Zhao, Shouzhou Zhang, Michael Lisby, Xin Liu, Xun Xu, Laigeng Li*, Sibo Wang*, Huan Liu*, Chromosome-scale genomes of commercial timber trees (Ochroma pyramidale,Mesua ferrea, andTectona grandis),Scientific Data,2023,10, 512.
联系方式
通讯地址：浙江省杭州市临安区武肃街666号国重大楼330
邮编：311300
邮箱：jsgui@zafu.edu.cn
