曹文瀚，博士，副教授

研究方向

以内吞体分选转运复合体（ESCRT）蛋白亚基BRAF、AtVPS2等为研究对象，探究内吞途径介导的质膜受体蛋白的液泡降解和循环途径；结合分子生物学、细胞生物学、遗传学和多组学分析手段，在模式植物拟南芥中研究内膜运输系统在植物逆境响应、生长发育过程中的调控作用和机理。上述基础理论将有助于林木抗逆性状的改良和培育。

学习与工作经历

分别于2010、2013年在北京师范大学获得理学学士、硕士学位。2020年6月于香港中文大学生命科学best365网页版登录细胞分子生物学系获得博士学位，导师姜里文教授。同年进入该单位从事科研工作，先后担任助理研究员（Research Assistant）,副研究员（Research Associate）。于2022年12月进入best365工作至今。

教学工作

研究生：植物细胞分子生物学研究技术与方法（部分专题）

发表论文（Publications）

一作/共一(^#，共同第一作者；^*，通讯作者)Asthe first or co-first author：

1. Wenhan Cao, Zhenping Li,Shuxian Huang, Yuwei Shi, Ying Zhu, Man Nga Lai, Pui Lok Lok, Xiangfeng Wang, Yong Cui, Liwen Jiang^*.2022. Correlation of vacuole morphology with stomatal lineage development by whole-cell electron tomography.Plant Physiology28;188(4):2085-2100. (一区top，IF:8.005)

2. Yong Cui^#,Wenhan Cao^#, Yilin He^#, Qiong Zhao, Mayumi Wakazaki, Xiaohong Zhuang, Jiayang Gao, Yonglun Zeng, Caiji Gao, Yu Ding, Hiu Yan Wong, Wing Shing Wong, Ham Karen Lam, Pengfei Wang, Takashi Ueda, Marcela Rojas-Pierce, Kiminori Toyooka, Byung-Ho Kang, Liwen Jiang^*. 2019. A whole-cell electron tomography model of vacuole biogenesis inArabidopsisroot cells.Nature Plants5: 95–105.(一区top，IF: 13.256)

3. Yong Cui^#, Yilin He^#,Wenhan Cao^#, Jiayang Gao, Liwen Jiang^*. 2018. The multivesicular body and autophagosome pathways in plants.Frontiers in Plant Science 9: 1837. (二区top，IF:4.106)

共同作者发表的代表性论文As the co-author：

1. Yonglun Zeng^#, Baiying Li^#, Shuxian Huang^#, Hongbo Li,Wenhan Cao, Yixuan Chen, Zhenping Li, Chao Yang, Jiayang Gao, Sze Wan Lo, Jierui Zhao, Jinbo Shen, Caiji Gao, Yasin Dagdas, Liwen Jiang^*.2023. The energy sensor SnRK1 Phosphorylates FREE1 to regulate autophagosome closure.Nature Communications14, 1768.(一区top，IF: 14.143)

2. Shuxian Huang, Zhiqi Liu,Wenhan Cao, Hongbo Li, Wenxin Zhang, Yong Cui, Shuai Hu, Mengqian Luo, Ying Zhu, Qiong Zhao, Lijuan Xie, Caiji Gao, Shi Xiao, Liwen Jiang^*. 2022. The plant ESCRT component FREE1 regulates peroxisome-mediated turnover of lipid droplets in germinating Arabidopsis seedlings.The Plant Cell27;34(11):4255-4273. (一区top，IF: 12.085)

3. Baiying Li, Fangfang Niu, Yonglun Zeng, Man Kei Tse, Cesi Deng, Liu Hong, Shengyu Gao, Sze Wan Lo, Wenhan Cao, Shuxian Huang, Yasin Dagdas, and Liwen Jiang*. Ufmylation reconciles salt stress-induced unfolded protein responses via ER-phagy in Arabidopsis.PNAS120 (5) :e2208351120. (一区top，12.779)

4. Baiying Li^#, Yonglun Zeng^#,Wenhan Cao, Wenxin Zhang, Lixin Cheng, Haidi Yin, Qian Wu, Xiangfeng Wang, Yan Huang, Wilson Chun Yu Lau, Zhong-Ping Yao, Yusong Guo^*, Liwen Jiang^*. 2021.A distinct giant coat protein complex II vesicle population in Arabidopsis thaliana.Nature Plants7: 1335-1346. (一区top，IF: 17.352)

5. Chunliang Liu, Yonglun Zeng, Hongbo Li, Chao Yang, Wenjin Shen, Min Xu, Zhidan Xiao, Tongsheng Chen, Baiying Li,Wenhan Cao, Liwen Jiang, Marisa S. Otegui, Caiji Gao^*.2021. A plant unique ESCRT component, FYVE4, regulates multivesicular endosome biogenesis and plant growth.New Phytologist231: 193-209. (一区top，IF: 10.151)

6. Ying Zhu^#, Changyang Ji^#,Wenhan Cao, Jinbo Shen, Qiong Zhao, Liwen Jiang^*. 2020. Identification and characterization of unconventional membrane protein trafficking regulators inArabidopsis: A genetic approach.Journal of Plant Physiology252: 153229. (一区top，IF: 3.549)

7. Qiong Zhao^#, Jinbo Shen^#, Caiji Gao^#, Yong Cui^#, Yongyi Wang, Jie Cui, Lixin Cheng,Wenhan Cao, Ying Zhu, Shuxian Huang, Qianzi Zhou, Cheuk Ka Leong, King Pong Leung, Xuemei Chen, Liwen Jiang^*.2019.RST1 is a FREE1 suppressor that negatively regulates vacuolar trafficking in Arabidopsis.The Plant Cell31: 2152-2168. (一区top，IF: 9.618)

8. Qiong Zhao, Ying Zhu,Wenhan Cao, Jinbo Shen, Yong Cui, Shuxian Huang, and Liwen Jiang^*. 2019.Genetic suppressor screen using an inducible FREE1-RNAi line to detect ESCRT genetic interactors in Arabidopsis thaliana.Methods in Molecular Biology1998: 273-289. (IF: 1.17)

9. Feifei Huang, Jing Luo, Tingting Ning,Wenhan Cao, Xi Jin, Heping, Zhao, Yingdian Wang, Shengcheng Han^*. 2017. Cytosolic and nucleosolic calcium signaling in response to osmotic and salt stresses are independent of each other in roots of Arabidopsis seedlings.Frontiers in Plant Science8:1648. (二区，IF: 5.753)

10. Qiong Zhao, Caiji Gao, PoShing Lee, Lin Liu, Shaofang Li, Tangjin Hu, Jinbo Shen, Shuying Pan, Hao Ye, Yunru Chen,Wenhan Cao, Yong Cui, Peng Zeng, Sheng Yu, Yangbin Gao, Liang Chen, Beixin Mo, Xin Liu, Shi Xiao, Yunde Zhao, Silin Zhong, Xuemei Chen, Liwen Jiang^*.2015. Fast-suppressor screening for new components in protein trafficking, organelle biogenesis and silencing pathway in Arabidopsis thaliana using DEX-inducible FREE1-RNAi plants.Journal of Genetics and Genomics42: 319-330. (JCR二区，IF: 4.275)

荣誉和奖励

1、2007年获北京师范大学2006-2007年度专业一等奖学金。

2、2011年获北京师范大学2010-2011学年优秀研究生奖。

通讯地址

浙江省杭州市临安区武肃街666号亚热带森林培育国家重点实验室413室。邮编：311300

Corresponding Address:Room 413, State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University (ZAFU), No.666 Wusu Street, Lin'an District, Hangzhou, Zhejiang, China.

E-mail:caowh@zafu..edu.cn /caocuhk@163.com